Gerontology Drugs (Products approved for use in Canada) Drug Class Generic Name(s) Trade Name(s) CARDIOVASCULAR DISEASES Diuretics Thiazide and Related Diuretics chlorthalidone hydrochlorothiazide HydroDiuril indapamide Lozide metolazone Zaroxolyn Loop Diuretics bumetanide Burinex ethacrynic acid Edecrin furosemide Lasix Potassium Sparing Diuretics amiloride Midamor triamterene Dyrenium Potassium Sparing Diuretic, Aldosterone Antagonist spironolactone Aldactone Combination Diuretics amiloride + hydrochlorothiazide Moduret spironolactone + hydrochlorothiazide Aldactazide triamterene + hydrochlorothiazide Dyazide ACE Inhibitors benazepril Lotensin captopril Capoten cilazapril Inhibace enalapril Vasotec fosinopril Monopril lisinopril Prinivil, Zestril perindopril Coversyl quinapril Accupril ramipril Altace trandolapril Mavik Drug Class Generic Name(s) Trade Name(s) ACE Inhibitors + Diuretic cilazapril + hydrochlorothiazide Inhibace Plus enalapril + hydrochlorothiazide Vaseretic lisinopril + hydrochlorothiazide Prinzide, Zestoretic quinapril + hydrochlorothiazide Accuretic AT1 Receptor Blockers (ARBs) candesartan Atacand eprosartan Teveten irbesartan Avapro losartan Cozaar telmisartan Micardis valsartan Diovan AT1 Receptor Blockers (ARBs) + Diuretic irbesartan + hydrochlorothiazide Avalide losartan + hydrochlorothiazide Hyzaar valsartan + hydrochlorothiazide Diovan-HCT Calcium Channel Blockers amlodipine Norvasc diltiazem Cardizem, Tiazac felodipine Plendil, Renedil flunarizine Sibelium nifedipine Adalat, Adalat XL nimodipine Nimotop verapamil Chronovera, Isoptin, Verelan Alpha Receptor Blockers doxazosin Cardura prazosin Minipress terazosin Hytrin Beta Receptor Blockers acebutolol Monitan, Sectral atenolol Tenormin bisoprolol Monocor esmolol Brevibloc metoprolol Betaloc, Lopresor Drug Class Generic Name(s) Trade Name(s) Beta Receptor Blockers nadolol Corgard oxprenolol Trasicor pindolol Visken propranolol Inderal sotalol Sotacor timolol Blocadren Mixed Alpha and Beta Blockers carvedilol Coreg labetalol Trandate Beta Blockers + Diuretic atenolol + chlorthalidone Tenoretic pindolol + hydrochlorothiazide Viskazide propranolol + hydrochlorothiazide Inderide timolol + hydrochlorothiazide Timolide Direct Vasodilators diazoxide Hyperstat, Proglycem hydralazine Apresoline minoxidil Loniten sodium nitroprusside Nitrates isosorbide dinitrate Cedocard SR, Isordil isosorbide-5-mononitrate Imdur, Ismo nitroglycerin Minitran, Nitro-Dur, Nitrol, Nitrolingual, Nitrong SR, Nitrostat, Transderm-Nitro, Trinipatch Inotropic Agents dobutamine Dobutrex dopamine Intropin milrinone lactate Primacor Central Adrenergic Agonists clonidine Catapres methyldopa Aldomet Peripheral Neuronal Blocking Agents guanethidine reserpine Drug Class Generic Name(s) Trade Name(s) Sympathomimetic Agents epinephrine Adrenalin isoproterenol Isuprel milrinone lactate Primacor norepinephrine Levophed phenylephrine Neo-Synephrine Antiplatelet Agents Adenosine Diphosphate Inhibitors dipyridamole Persantine clopidogrel Plavix sulfinpyrazone Anturan ticlopidine Ticlid Glycoprotein IIb/IIIa Receptor Inhibitors abciximab Reopro eptifibatide Integrilin tirofiban Aggrastat Thromboxane-A2 Inhibitors acetylsalicylic acid Aspirin, Ecotrin, Entrophen Combination Products acetylsalicylic acid + dipyridamole SR Aggrenox Anticoagulant Agents Heparin heparin sodium Hepalean, Heparin Leo Heparinoid danaparoid Orgaran Low Molecular Weight Heparins dalteparin Fragmin enoxaparin Lovenox nadroparin Fraxiparine tinzaparin Innohep Direct Thrombin Inhibitors argatroban Argatroban bivalirudin Angiomax lepirudin Refludan Vitamin K Antagonists warfarin Coumadin Various Anticoagulants antithrombin III (human) Thrombate III fondaparinux Arixtra Drug Class Generic Name(s) Trade Name(s) Thrombolytic Agents alteplase (rtPA) Activase reteplase Retavase streptokinase Kabikinase, Streptase tenecteplase TNKase Lipid Lowering Agents Bile acid sequestrants cholestyramine Questran colestipol Colestid Cholesterol absorption inhibitor ezetimibe Ezetrol HMG-CoA reductase inhibitors atorvastatin Lipitor fluvastatin Lescol lovastatin Mevacor pravastatin Pravachol rosuvastatin Crestor simvastatin Zocor Niacin derivatives niacin (nicotinic acid) Fibrates bezafibrate Bezalip fenofibrate Lipidil Micro, Lipidil Supra Gemfibrozil Lopid Cholesterol Absorption Inhibitor Ezetimibe Ezetrol Drug Class Generic Name(s) Trade Name(s) Antiarrhythmic Agents Class IA disopyramide Rythmodan procainamide Procan, Pronestyl quinidine bisulfate Biquin Durules quinidine sulfate Quinidex Extentabs Class IB lidocaine Xylocard mexiletine Mexitil Class IC flecainide Tambocor propafenone Rythmol Class II (beta-blockers) esmolol Brevibloc propranolol Inderal sotalol Sotacor Class III amiodarone Cordarone bretylium ibutilide Corvert Class IV (Calcium Channel Blockers) diltiazem Cardizem, Tiazac verapamil Chronovera, Isoptin, Verelan Miscellaneous adenosine Adenocard digoxin Lanoxin Drug Class Generic Name(s) Trade Name(s) PARKINSON’S DISEASE Anticholinergic Agents benztropine Cogentin biperiden Akineton diphenhydramine Benadryl ethopropazine Parsitan orphenadrine citrate Norflex orphenadrine hydrochloride Disipal procyclidine Kemadrin trihexyphenidyl Dopamine Agonists bromocriptine Parlodel cabergoline** Dostinex pergolide Permax pramipexole Mirapex ropinirole Requip Dopamine Precursors levodopa Dopamine Precursors and Decarboxylase Inhibitors levodopa/benserazide Prolopa levodopa/carbidopa Sinemet, Sinemet CR Monoamine Oxidase (MAO) Inhibitors, Selective (Type B) selegiline Eldepryl Various Dopaminergic Agents amantadine Symmetrel COMT inhibitors entacapone Comtan tolcapone*** ** Cabergoline is not yet approved in Canada for use for Parkinson’s Disease *** Available only via Health Canada’s Special Access Program Drug Class Generic Name(s) Trade Name(s) ALZHEIMER’S DISEASE Centrally Acting Cholinesterase Inhibitors donepezil Aricept galantamine Reminyl rivastigime Exelon Antipsychotics chlorpromazine Largactil clozapine Clozaril flupenthixol Fluanxol fluphenazine Modecate, Moditen haloperidol Haldol loxapine Loxapac mesoridazine Serentil methotrimeprazine Nozinan olanzapine Zyprexa, Zyprexa Zydis, Zyprexa Intramuscular pericyazine Neuleptil perphenazine Trilafon pimozide Orap pipotiazine Piportil promazine quetiapine Seroquel risperidone Risperdal, Risperdal M-Tab, Risperdal Consta thioproperazine Majeptil thioridazine Mellaril thiothixene Navane trifluoperazine Stelazine zuclopenthixol Clopixol N-methyl-D-aspartate (NMDA) Receptor Antagonist memantine Ebixa Drug Class Generic Name(s) Trade Name(s) DEPRESSION Non-Selective Cyclic Antidepressants (TCA) amitriptyline Elavil clomipramine Anafranil desipramine Norpramin doxepin Sinequan, Triadapin imipramine Tofranil maprotiline Ludiomil nortriptyline Aventyl trimipramine Surmontil Irreversible Monoamine Oxidase Inhibitors (MAOI) phenelzine Nardil tranylcypromine Parnate Reversible Inhibitor of Monoamine Oxidase-A (RIMA) moclobemide Manerix Selective Serotonin Reuptake Inhibitors (SSRI) citalopram Celexa fluoxetine Prozac fluvoxamine Luvox paroxetine Paxil, Paxil CR sertraline Zoloft Selective Serotonin Norepinephrine Reuptake Inhibitors (SSNRI) venlafaxine Effexor XR Serotonin-2 Antagonists/ Reuptake Inhibitors (SARI) trazodone Desyrel Noradrenergic/ Specific Serotonergic Agents (NaSSA) mirtazapine Remeron Norepinephrine Dopamine Reuptake Inhibitor (NDRI) bupropion Wellbutrin SR (for treatment of depression), Zyban Smoking Cessation Aid) Drug Class Generic Name(s) Trade Name(s) STROKE Antiplatelet Agents Adenosine Diphosphate Inhibitors dipyridamole Persantine dipyridamole + ASA Aggrenox sulfinpyrazone Anturan Fibrinogen-Platelet Binding Inhibitors clopidogrel Plavix ticlopidine Ticlid Thromboxane-A2 Inhibitors acetylsalicylic acid Aspirin, Entrophen Anticoagulant Agents Heparins heparin Hepalean Low Molecular Weight Heparins dalteparin Fragmin enoxaparin Lovenox nadroparin Fraxiparine tinzaparin Innohep Vitamin K Antagonists nicoumalone Sintrom warfarin Coumadin Various Anticoagulants ancrod Viprinex antithrombin III (human) Thrombate III danaparoid Orgaran lepirudin Refludan Subarachnoid Hemorrhage Adjunct — Calcium Channel Blocking agent nimodipine Nimotop Antifibrinolytic Agents aminocaproic acid Amicar aprotinin Trasylol tranexamic acid Cyklokapron Thrombolytic Agents alteplase Activase rt-PA reteplase Retavase streptokinase Streptase tenecteplase TNKase Drug Class Generic Name(s) Trade Name(s) DIABETES Insulins, Pork insulin regular Iletin II Regular insulin NPH Iletin II NPH Insulins, Human insulin regular Humulin R, Novolin ge Toronto insulin lente Humulin L insulin NPH Humulin N, Novolin ge NPH insulin ultralente Humulin U Insulins, Human, Mixed (Regular/NPH) reg/NPH 10/90 Novolin ge 10/90 reg/NPH 20/80 Humulin 20/80, Novolin ge 20/80 reg/NPH 30/70 Humulin 30/70, Novolin ge 30/70 reg/NPH 40/60 Novolin ge 40/60 reg/NPH 50/50 Novolin ge 50/50 Insulin Analogues insulin aspart NovoRapid insulin glargine Lantus (approved, but not yet marketed in Canada) insulin lispro Humalog insulin lispro 25% + neutral protamine lispro 75% Humalog Mix 25 Sulfonylureas chlorpropamide gliclazide Diamicron, Diamicron MR glimepiride Amaryl glyburide Diaβeta, Euglucon tolbutamide Meglitinides nateglinide Starlix repaglinide Gluconorm Biguanide metformin Glucophage α-Glucosidase Inhibitor acarbose Prandase Drug Class Generic Name(s) Trade Name(s) Thiazolidinediones (glitazones) pioglitazone Actos rosiglitazone Avandia Combination Biguanide + Glitazone metformin + rosiglitazone Avandamet Hyperglycemic Agents diazoxide Proglycem glucagon Drug Class Generic Name(s) Trade Name(s) OSTEOARTHRITIS Analgesics Topical capsaicin Zostrix methyl salicylate or triethanolamine (or trolamine) salicylate Antiphlogistine Rub A-535, Bengay, Myoflex Systemic acetaminophen Abenol, Atasol, Tempra, Tylenol Nonsteroidal Anti-inflammatory Drugs (NSAIDs) Salicylates acetylsalicylic acid (ASA) Aspirin, Entrophen Pyrazole Derivatives phenylbutazone Other NSAIDs diclofenac sodium Voltaren diflunisal etodolac Ultradol fenoprofen Nalfon floctafenine Idarac flurbiprofen Ansaid, Froben ibuprofen Advil, Motrin indomethacin Indocid ketoprofen Orudis, Orudis E, Oruvail ketorolac Toradol mefenamic acid Ponstan nabumetone Relafen naproxen Naprosyn naproxen sodium Anaprox oxaprozin Daypro piroxicam sulindac tenoxicam tiaprofenic acid Surgam tolmetin Tolectin Drug Class Generic Name(s) Trade Name(s) NSAID + prostaglandin diclofenac + misoprostol Arthrotec Topical NSAID diclofenac Pennsaid COX-2 Selective Inhibitors celecoxib Celebrex meloxicam Mobicox valdecoxib Bextra Corticosteroids (for intra-articular injection) methylprednisolone acetate Depo-Medrol triamcinolone acetonide Kenalog triamcinolone diacetate triamcinolone hexacetonide Aristospan Viscosupplements hyaluronate sodium Supartz hyaluronic acid Suplasyn hylan G-F 20 Synvisc Nutraceuticals chondroitin glucosamine Drug Class Generic Name(s) Trade Name(s) OSTEOPOROSIS Bisphosphonates alendronate Fosamax etidronate disodium Didronel etidronate + calcium carbonate Didrocal risedronate Actonel Calcitonin calcitonin salmon, injection Calcimar, Caltine calcitonin salmon, intranasal Miacalcin Estrogens conjugated estrogens Premarin estropipate Ogen micronized estradiol Estrace transdermal estradiol Climara, Estraderm, Estradot, Estrogel, Oesclim, Vivelle transdermal estradiol + norethindrone acetate Estalis Sequi Selective Estrogen Receptor Modulator raloxifene Evista Vitamin D analogues cholecalciferol (vitamin D3)** ergocalciferol (vitamin D2) Ostoforte alfacalcidol One-Alpha calcitriol Calcijex , Rocaltrol Parathyroid hormone bone formation agent teriparatide Forteo ** Component of multiple vitamin products, calcium and vitamin D products available as 400 IU and 1000 IU in single entity products Drug Class Generic Name(s) Trade Name(s) INFECTIOUS BACTERIAL DISEASES Antibiotics Natural Penicillins penicillin G – oral, inj. Crystapen penicillin G benzathine – inj. Bicillin L-A** penicillin V – oral Pen-Vee Penicillinase-resistant (Antistaphyloccal) Penicillins cloxacillin – oral, inj. Extended-spectrum Penicillins (Aminopenicillins) amoxicillin – oral Amoxil ampicillin – oral, inj. Ampicin bacampicillin – oral Penglobe pivampicillin – oral Pondocillin pivmecillinam – oral Selexid Anti-Pseudomonal Penicillins piperacillin sodium – inj Pipracil Penicillin/Beta-lactamase Inhibitor Combinations amoxicillin/clavulanate – oral Clavulin piperacillin/tazobactam – inj. Tazocin ticarcillin/clavulanate – inj. Timentin First Generation Cephalosporins cefadroxil – oral Duricef cefazolin – inj. Kefzol cephalexin – oral Second Generation Cephalosporins cefaclor – oral Ceclor cefotetan – inj. Cefotan cefoxitin – inj. cefprozil – oral Cefzil cefuroxime – inj. Kefurox, Zinacef cefuroxime axetil – oral Ceftin ** Available only via Health Canada’s Special Access Program Drug Class Generic Name(s) Trade Name(s) Third Generation Cephalosporins cefixime – oral Suprax cefotaxime – inj Claforan ceftazidime – inj Fortaz, Tazidime ceftizoxime – inj Cefizox ceftriaxone – inj Rocephin Fourth Generation Cephalosporins cefepime – inj Maxipime Carbapenems ertapenem – inj. Ivanz imipenem-cilastatin – inj. Primaxin meropenem – inj. Merrem Aminoglycosides amikacin – inj. Amikin gentamicin – inj. Garamycin netilmicin – inj. Netromycin tobramycin– inj., inhalation Nebcin, Tobi Macrolides and Ketolides azithromycin — oral, inj. Zithromax clarithromycin — oral Biaxin, Biaxin XL erythromycin — oral, inj. EES, Erybid, Eryc, Erythrocin, Erythromid, PCE telithromycin – oral Ketec Glycopeptides vancomycin – oral, inj. Vancocin Tetracyclines doxycycline – oral, inj.** Vibra-Tabs minocycline – oral Minocin tetracycline – oral Sulfonamides, Combination Products sulfadiazine + trimethoprim (co-trimazine) – oral Coptin sulfamethoxazole + trimethoprim (co-trimoxazole) – oral, inj. Septra sulfisoxazole + erythromycin – oral Pediazole ** Available only via Health Canada’s Special Access Program Drug Class Generic Name(s) Trade Name(s) Fluoroquinolones ciprofloxacin – oral, inj. Cipro gatifloxacin – oral, inj. Tequin levofloxacin – oral, inj. Levaquin moxifloxacin – oral, inj Avelox norfloxacin – oral ofloxacin – oral Floxin Various Antibiotics chloramphenicol – oral, inj. Chloromycetin clindamycin – oral, inj., vaginal cream Dalacin C fusidic acid – oral, inj., topical, ophthalmic Fucidin linezolid – oral, inj. Zyvoxam metronidazole – oral, inj., vaginal cream Flagyl quinupristin + dalfopristin – inj. Synercid Urinary Anti-infectives fosfomycin Monurol methenamine HipRex, Mandelamine nalidixic acid NegGram nitrofurantoin MacroBID, Macrodantin trimethoprim Proloprim trimethoprim/sulfadiazine (co-trimazine) Coptin Drug Class Generic Name(s) Trade Name(s) INFECTIOUS VIRAL DISEASES Neuraminidase Inhibitors oseltamivir — oral Tamiflu zanamivir — inhaled Relenza Nucleoside Antivirals ribavirin – aerosol, inj.** Virazole ribavirin (oral) + interferon alfa-2b (inj.) Rebetron Other Antivirals amantadine — oral Symmetrel Influenza Vaccine influenza virus vaccine (inactivated, split-virus) Fluzone, Fluviral S/F, Vaxigrip ** Available only via Health Canada’s Special Access Program Drug Class Generic Name(s) Trade Name(s) CANCER Alkylating Agents Alkyl sulphonates busulfan Myleran Ethylene Imines thiotepa Methylhydrazine and Triazine Derivatives dacarbazine DTIC procarbazine Natulan temozolomide Temodal Nitrogen Mustard Analogues chlorambucil Leukeran cyclophosphamide Cytoxan, Procytox estramustine Emcyt ifosfamide Ifex mechlorethamine Mustargen melphalan Alkeran Nitrosoureas carmustine (BCNU) BiCNU lomustine (CCNU) CeeNU streptozocin Zanosar Alkylator-like Agents Platinum Complexes carboplatin Paraplatin cisplatin Platinol oxaliplatin Eloxatin (widely used, but not approved for use in Canada) Antimetabolites Folic Acid Analogues methotrexate raltitrexed Tomudex Purine Analogues cladribine Leustatin fludarabine Fludara mercaptopurine (6-MP) Purinethol thioguanine Lanvis Pyrimidine Analogues capecitabine Xeloda cytarabine (Ara-C) Cytosar cytarabine liposome DepoCyt 5-fluorouracil (5-FU) Adrucil, Efudex, Fluoroplex Drug Class Generic Name(s) Trade Name(s) Cytidine Analogues gemcitabine Gemzar Urea Derivatives hydroxyurea Hydrea Various Enzymes asparaginase Kidrolase pegaspargase Oncaspar Antitumour Antibiotics Anthracyclines daunorubicin Cerubidine doxorubicin Adriamycin doxorubicin pegylated liposomes Caelyx epirubicin Pharmorubicin idarubicin Idamycin valrubicin Valtaxin Actinomycins dactinomycin (actinomycin D) Cosmegen Various Cytotoxic Antibiotics bleomycin Blenoxane mitomycin C Mutamycin mitoxantrone Novantrone pentostatin Nipent Plant Alkaloids and Other Natural Products Camptothecin Derivatives irinotecan Camptosar topotecan Hycamtin Epipodophyllotoxins etoposide (VP-16) Vepesid teniposide Vumon Taxanes docetaxel Taxotere paclitaxel Taxol Vinca Alkaloids and Analogues vinblastine vincristine vindesine Eldisine vinorelbine Navelbine Drug Class Generic Name(s) Trade Name(s) Various Antineoplastics amsacrine Amsa P-D porfimer Photofrin procarbazine Natulan rituximab Rituxan trastuzumab Herceptin tretinoin (all-trans retinoic acid), systemic Vesanoid Tyrosine Kinase Inhibitors erlotinib Tarceva gefitinib Iressa imatinib Gleevec Monoclonal Antibodies rituximab Rituxan trastuzumab Herceptin Various Antineoplastics amsacrine Amsa PD porfimer Photofrin tretinoin (all-trans retinoic acid), systemic Vesanoid Hormonal Agents Adrenocorticosteroids dexamethasone Decadron prednisone Adrenocorticosteroid Suppressants mitotane Lysodren Aromatase Inhibitors anastrozole Arimidex exemestane Aromasin letrozole Femara Antiandrogens bicalutamide Casodex cyproterone Androcur flutamide Euflex nilutamide Anandron Drug Class Generic Name(s) Trade Name(s) Antiestrogens tamoxifen Nolvadex, Tamofen, Tamone Estrogens conjugated estrogen ethinyl estradiol diethylstilbestrol Honvol Gonadotropin Releasing Hormone Analogues leuprolide Lupron Luteinizing Hormone Releasing Hormone Agonists buserelin Suprefact goserelin Zoladex Progestins medroxyprogesterone Depo-Provera, Provera megestrol acetate Megace Somatostatin Analogue octreotide Sandostatin Immunomodulating Agents Biological Response Modifiers aldesleukin Proleukin interferon alfa-2a Roferon interferon alfa-2b Intron A Immunotherapeutic Agents BCG vaccine (Bacillus Calmette Guerin) Immucyst, Oncotice, Pacis melanoma theraccine Melacine Agents for Prevention of Chemotherapy-Induced Toxicity amifostine Ethyol dexrazoxane Zinecard leucovorin calcium (or folinic acid) mesna Uromitexan Antirejection Agent tacrolimus Prograf Drug Class Generic Name(s) Trade Name(s) GENITOURINARY DISORDERS Urinary Incontinence Sympathomimetic Agents epinephrine Adrenalin isoproterenol Isuprel norepinephrine Levophed phenylephrine Neo-Synephrine pseudoephedrine Eltor 120, Sudafed Anticholinergic / Antispasmodic Agents dicyclomine Bentylol flavoxate Urispas oxybutynin Ditropan propantheline Propanthel, Pro-Banthine tolterodine Detrol Erectile Dysfunction Oral PDE-5 inhibitors sildenafil Viagra tadalafil Cialis vardenafil Levitra Miscellaneous therapies bromocriptine Parlodel trazodone Desyrel testosterone – oral Andriol testosterone – topical Androgel, Androderm testosterone – injection Delatestryl yohimbine Yocon Intraurethral Agents alprostadil MUSE Intracavernosal Injections alprostadil Caverject papaverine phentolamine Rogitine Drug Class Generic Name(s) Trade Name(s) Benign Prostatic Hypertrophy 5-alpha-reductase inhibitor dutasteride Avodart finasteride Proscar Alpha-adrenergic Antagonists alfuzosin Xatral doxazosin Cardura tamsulosin Flomax terazosin Hytrin Drug Class Generic Name(s) Trade Name(s) INSOMNIA Hypnotics and Sedatives Aldehydes and Derivatives chloral hydrate paraldehyde Barbiturates amobarbital Amytal pentobarbital Nembutal phenobarbital Barbilixir, Luminal secobarbital Seconal Benzodiazepine Derivatives alprazolam Xanax bromazepam Lectopam clorazepate Tranxene diazepam Valium, Vivol flurazepam Dalmane lorazepam Ativan midazolam Versed nitrazepam Mogadon oxazepam Serax temazepam Restoril triazolam Halcion Cyclopyrrolones zopiclone Imovane Pyrazolopyrimidines zaleplon Starnoc Various Hypnotics and Sedatives ethchlorvynol Placidyl MALNUTRITION Growth hormone Somatrem Protropin Somatropin Humatrope, Nutropin, Saizen Drug Class Generic Name(s) Trade Name(s) GLAUCOMA Alpha agonists apraclonidine Lopidine brimonidine tartrate Alphagan, Alphagan P Adrenergic agonists dipivefrin Propine Beta-blockers betaxolol Betoptic S levobunolol Betagan Liquifilm timiolol maleate Timoptic, Timoptic XE Carbonic anhydrase inhibitors brinzolamide Azopt dorzolamide Trusopt Combination carbonic anhydrase inhibitor + beta-blocker dorzolamide + timolol maleate Cosopt Cholinergic agonists pilocarpine Pilopine HS4 Combination cholinergic agonist + beta-blocker pilocarpine + timolol maleate Timpilo 2, Timpilo 4 Prostaglandin analogues bimatoprost Lumigan latanoprost Xalatan travoprost Travatan unoprostone Rescula