Nervous System Drugs (products approved for use in Canada) Drug Class Generic Name Trade Name Anaesthetics, General Barbiturates thiopental sodium Pentothal Halogenated Hydrocarbons desflurane Suprane enflurane halothane isoflurane Forane sevoflurane Sevorane Opioids alfentanil Alfenta fentanyl citrate remifentanil Ultiva sufentanil citrate Sufenta Various General Anaesthetics ketamine Ketalar midazolam Versed propofol Diprivan Anaesthetics, Local Amides articaine Astracaine bupivacaine Marcaine, Sensorcaine lidocaine Xylocaine mepivacaine Carbocaine, Polocaine prilocaine Citanest ropivacaine Naropin Esters of Amino Benzoic Acid benzocaine chloroprocaine Nesacaine cocaine procaine Novocain tetracaine Ametop, Pontocaine Drug Class Generic Name Trade Name Neuromuscular Blocking Agents Depolarizing Agents, Choline Derivatives succinylcholine chloride Quelicin Nondepolarizing Agents, Quaternary Ammonium Compounds atracurium Tracrium cisatracurium Nimbex doxacurium Nuromax mivacurium Mivacron pancuronium Pavulon rocuronium Zemuron vecuronium Norcuron Sympathomimetic Agents (alpha1, beta1, beta2 –receptor agonists) Acting on a1 , b1 , b2 ephedrine epinephrine Adrenalin epinephrine, racemic Vaponefrin norepinephrine Levophed Acting on a1 primarily pseudoephedrine Sudafed phenylephrine Mydfrin, Neo-Synephrine Acting on b1 primarily dopamine Intropin dobutamine Dobutrex Acting on b2 primarily fenoterol Berotec formoterol Foradil , Oxeze orciprenaline salbutamol Ventolin, Airomir salmeterol Serevent terbutaline Bricanyl Drug Class Generic Name Trade Name Alpha Adrenergic Antagonists Alpha1-selective Antagonists alfuzosin Xatral doxazosin Cardura prazosin Minipress tamsulosin Flomax terazosin Hytrin Non-selective Alpha Antagonist phentolamine Rogitine Beta Adrenergic Antagonists Non-selective Beta Antagonists nadolol Corgard oxprenolol Trasicor pindolol Visken propranolol Inderal sotalol Sotacor timolol Alpha1 and Beta-Adrenergic Blocking Agents carvedilol Coreg labetalol Trandate Beta1-selective Antagonists acebutolol Monitan, Sectral atenolol Tenormin metoprolol Betaloc bisoprolol Monocor esmolol Brevibloc Centrally Acting Antiadrenergic Agents clonidine Catapres methyldopa reserpine Post-Ganglionic Blocking Agents guanethidine Drug Class Generic Name Trade Name Cholinergic Agents Direct-acting Cholinergics bethanechol methacholine Provocholine Indirect-acting Cholinergics, Reversible (Short-acting) neostigmine Prostigmin pyridostigmine Mestinon Indirect-acting Cholinergics, Irreversible (Long-acting) edrophonium chloride Enlon, Tensilon Anticholinergic Agents atropine dicyclomine Bentylol glycopyrrolate Robinul ipratropium Atrovent Oxybutinin oral Ditropan, Ditropan XL oxybutinin transdermal patch Oxytrol propantheline Pro-Banthine tiotropium Spiriva tolterodine Detrol Antiparkinsonian Agents Anticholinergic Agents benztropine Cogentin biperiden Akineton diphenhydramine Benadryl ethopropazine Parsitan orphenadrine citrate Norflex orphenadrine hydrochloride procyclidine Kemadrin trihexyphenidyl Dopamine Agonists bromocriptine Parlodel cabergoline Dostinex pergolide Permax pramipexole Mirapex ropinirole Requip Drug Class Generic Name Trade Name Antiparkinsonian Agents Dopamine Precursors levodopa Dopamine Precursors and Decarboxylase Inhibitors levodopa/benserazide Prolopa levodopa/carbidopa Sinemet Monoamine Oxidase (MAO) Inhibitors, Selective (Type B) selegiline Various Dopaminergic Agents amantadine Symmetrel COMT Inhibitors entacapone Comtan tolcapone** Myasthenia Gravis Agents Peripherally Acting Anticholinesterase Agents neostigmine Prostigmin pyridostigmine Mestinon, Mestinon SR Immuno- suppressives azathioprine Imuran cyclophosphamide Cytoxan, Procytox cyclosporine Neoral intravenous immune globulin (IVIG) Gamimune methotrexate mycophenolate mofetil CellCept prednisone Alzheimer’s disease Centrally Acting Cholinesterase Inhibitors donepezil Aricept galantamine Reminyl rivastigime Exelon NMDA receptor antagonist memantine Ebixa ** Available only via Health Canada’s Special Access Program Drug Class Generic Name Trade Name Antipsychotics chlorpromazine Largactil clozapine Clozaril flupenthixol Fluanxol fluphenazine Modecate haloperidol Haldol loxapine Loxapac methotrimeprazine Nozinan olanzapine Zyprexa pericyazine Neuleptil perphenazine Trilafon pimozide Orap pipotiazine Piportil promazine quetiapine Seroquel risperidone Risperdal thioproperazine Majeptil thioridazine thiothixene Navane trifluoperazine zuclopenthixol Clopixol Agents used in Multiple Sclerosis azathioprine Imuran cladribine Leustatin cyclophosphamide Cytoxan, Procytox glatiramer Copaxone interferon beta-1a Avonex, Rebif interferon beta-1b Betaseron intravenous immune globulin Gamimune N methotrexate methylprednisolone Medrol, Solu-Medrol, Depo-Medrol mitoxantrone Novantrone Drug Class Generic Name Trade Name Agents to Combat Fatigue in Multiple Sclerosis amantadine Symmetrel L-carnitine Carnitor methylphenidate Ritalin modafinil Alertec Anticonvulsants Barbiturates and Derivatives phenobarbital primidone Benzodiazepine Derivatives clobazam Frisium clonazepam Rivotril diazepam Valium, Vivol, Diastat (gel) lorazepam Ativan nitrazepam Mogadon Carboxylic Acid Derivatives divalproex sodium Epival valproic acid Depakene Gamma-Aminobutyric Acid (GABA) Derivatives gabapentin Neurontin Hydantoin Derivatives fosphenytoin Cerebyx phenytoin Dilantin Iminostilbene Derivatives carbamazepine Tegretol, Tegretol CR oxcarbazepine Trileptal Pyrrolidine derivative levetiracetam Keppra Succinimide Derivatives ethosuximide Zarontin methsuximide Celontin Various Anticonvulsants lamotrigine Lamictal magnesium sulfate paraldehyde topiramate Topamax vigabatrin Sabril Drug Class Generic Name Trade Name Antispastics baclofen Lioresal botulinum toxin Botox carbamazepine Tegretol clonidine Catapres clonazepam Rivotril cyclobenzaprine Flexeril dantrolene Dantrium diazepam Valium divalproex sodium Epival phenytoin Dilantin gabapentin Neurontin selegiline tizanidine Zanaflex valproic acid Depakene Agents to Combat Ataxia / Tremor in Multiple Sclerosis carbamazepine Tegretol clonazepam Rivotril hyoscine Buscopan isoniazid ondansetron Zofran primidone Nonsteroidal Anti-inflammatory Drugs  (NSAIDs) Acetic Acid Derivatives  (including Indole Derivatives) diclofenac Voltaren etodolac Ultradol indomethacin Indocid ketorolac Toradol sulindac tolmetin Tolectin Anthranilic Acids floctafenine Idarac mefenamic acid Drug Class Generic Name Trade Name Nonsteroidal Anti-inflammatory Drugs (NSAIDs) Oxicams piroxicam tenoxicam Propionic Acid Derivatives fenoprofen Nalfon flurbiprofen Ansaid, Froben ibuprofen Advil, Motrin ketoprofen Orudis SR naproxen Naprosyn naproxen sodium Anaprox oxaprozin Daypro tiaprofenic acid Surgam Salicylic Acid Derivatives acetylsalicylic acid (ASA) Aspirin, Entrophen choline magnesium trisalicylate Trilisate diflunisal Various Nonsteroidal Anti inflammatory Agents nabumetone Relafen phenylbutazone COX-2 Inhibitors celecoxib Celebrex meloxicam Mobicox Opioid analgesics Diphenylheptane Derivatives methadone Metadol propoxyphene Darvon-N, 642 Tablets Natural Opium Alkaloids – Phenanthrene Derivatives codeine Codeine Contin hydrocodone Hycodan hydromorphone Dilaudid, Hydromorph Contin morphine Kadian, M-Eslon, M.O.S., MS Contin oxycodone Oxycontin, Oxy IR, Supeudol Drug Class Generic Name Trade Name Opioid analgesics Phenylpiperidine Derivatives alfentanil Alfenta fentanyl citrate inj. Duragesic, Fentanyl citrate inj. meperidine Demerol sufentanil Sufenta Synthetic Opioid Agonists fentanyl citrate inj. Fentanyl citrate fentanyl patch Duragesic methadone Metadon Opioid Partial Agonists butorphanol nalbuphine Nubain pentazocine Talwin Opioid antagonists naloxone Narcan naltrexone ReVia Neuropathic Pain Anticonvulsants carbamazepine Tegretol divalproex sodium Epival gabapentin Neurontin phenytoin Dilantin valproic acid Depakene Antidepressants amitriptyline Elavil nortriptyline Aventyl venlafaxine Effexor XR Local Anaesthetics bupivicaine Marcaine lidocaine Xylocaine mexilitine Mexitil Antispastic baclofen Lioresal Alpha-adrenergic Agents clonidine Catapres Topical Agents capsaicin Zostrix topical ASA (extemporaneous preparation) Drug Class Generic Name(s) Trade Name(s) Antidepressants Selective Serotonin Reuptake Inhibitors citalopram Celexa escitalopram Cipralex fluoxetine Prozac fluvoxamine Luvox paroxetine Paxil, Paxil CR sertraline Zoloft Serotonin Norepinephrine Reuptake Inhibitor venlafaxine Effexor XR Cyclic Antidepressants amitriptyline Elavil clomipramine Anafranil desipramine Norpramin doxepin Sinequan imipramine Tofranil maprotiline nortriptyline Aventyl trimipramine Surmontil Triazolopyridines trazodone Desyrel Monoamine Oxidase (MAO) Inhibitors, Nonselective (Types A, B) phenelzine Nardil tranylcypromine Parnate Monoamine Oxidase (MAO) Inhibitors,Selective moclobemide Manerix Various Antidepressants bupropion Wellbutrin SR, Zyban tryptophan Tryptan mirtazapine Remeron, Remeron RD Drug Class Generic Name(s) Trade Name(s) Agents Used in Bipolar Disorder Lithium Salts lithium carbonate Carbolith, Duralith, Lithane Iminostilbene Derivatives carbamazepine Tegretol, Tegretol CR Carboxylic Acid Derivatives valproate, valproic acid, divalproex sodium Depakene, Epival Various Adjunctive Agents tryptophan Tryptan Anxiolytics Benzodiazepine Derivatives alprazolam Xanax bromazepam Lectopam chlordiazepoxide clorazepate diazepam Valium, Vivol lorazepam Ativan oxazepam Various Anxiolytics buspirone Buspar hydroxyzine Atarax meprobamate Hypnotics and Sedatives Barbiturates amobarbital Amytal pentobarbital sodium Nembutal Sodium phenobarbital secobarbital Seconal secobarbital + amobarbital Tuinal Benzodiazepine Derivatives flurazepam hydrochloride Dalmane midazolam hydrochloride Versed nitrazepam Mogadon temazepam Restoril triazolam Halcion Drug Class Generic Name(s) Trade Name(s) Hypnotics and Sedatives cont’d Various Hypnotics and Sedatives chloral hydrate ethchlorvynol Placidyl paraldehyde propofol Diprivan zaleplon Starnoc zopiclone Imovane Antiviral Agents for Herpes Zoster acyclovir Zovirax famciclovir Famvir valacyclovir Valtrex Headache Opioids butorphanol (nasal spray) Ergot Alkaloids dihydroergotamine (IV, SC, IM) DHE dihydroergotamine mesylate (nasal spray) Migranal ergonovine (inj) ergotamine/belladonna/ phenobarbital Bellergal Spacetabs ergotamine/caffeine (oral, suppository) Cafergot ergotamine/caffeine/ diphenydramine Ergodryl Neuroleptics chlorpromazine Largactil haloperidol Haldol methotrimeprazine Nozinan prochlorperazine Stemetil Corticosteroids prednisone Antimania Agents lithium carbonate Carbolith, Duralith, Lithane Serotonin Antagonists methysergide Sansert cyproheptadine Periactin pizotifen Sandomigran Drug Class Generic Name Trade Name Headache Serotonin Receptor Agonists almotriptan (oral) Axert eletriptan (oral) Relpax naratriptan (oral) Amerge rizatriptan (oral) Maxalt sumatriptan (oral, SC) Imitrex zolmitriptan (oral, nasal) Zomig Beta-adrenergic Blockers atenolol Tenormin metoprolol Betaloc, Betaloc Durules, Lopresor nadolol Corgard propranolol Inderal-LA timolol Anticonvulsants divalproex sodium Epival gabapentin Neurontin topiramate Topamax Antidepressants amitriptyline Elavil nortriptyline Aventyl phenelzine Nardil tranylcypromine Parnate Calcium Channel Blockers diltiazem Cardizem, Cardizem CD, Tiazac flunarizine Sibelium verapamil Isoptin, Isoptin SR NSAIDs fenoprofen Nalfon flurbiprofen Ansaid ibuprofen Motrin ketoprofen Orudis SR naproxen Naprosyn Vitamin B2 riboflavin Drug Class Generic Name Trade Name Antiplatelet Agents Adenosine Diphosphate Inhibitors clopidogrel Plavix dipyridamole Persantine sulfinpyrazone Anturan ticlopidine Ticlid Glycoprotein IIb/IIIa Receptor Inhibitors abciximab Reopro eptifibatide Integrilin tirofiban Aggrastat Thromboxane-A2 Inhibitors acetylsalicylic acid Aspirin, Entrophen Combination Products acetylsalicylic acid + dipyridamole SR Aggrenox Anticoagulant Agents Heparins heparin Hepalean, Heparin Leo Heparinoid danaparoid Orgaran Low Molecular Weight Heparins dalteparin Fragmin enoxaparin Lovenox nadroparin Fraxiparine tinzaparin Innohep Direct Thrombin Inhibitors argatroban Argatroban bivalirudin Angiomax lepirudin Refludan Vitamin K Antagonists warfarin Coumadin Various Anticoagulants antithrombin III (human) Thrombate III fondaparinux Arixtra Subarachnoid Hemorrhage Adjunct — Calcium Channel Blocking agent nimodipine Nimotop Antifibrinolytic Agents aminocaproic acid Amicar aprotinin Trasylol tranexamic acid Cyklokapron Drug Class Generic Name Trade Name Thrombolytic Agents alteplase Activase rt-PA anistreplase Eminase reteplase Retavase streptokinase Kabikinase, Streptase tenecteplase (TNK) TNKase
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